| Value |
5
days
|
| Organism |
Rat Rattus norvegicus |
| Reference |
Hirsch CA, Hiatt HH. Turnover of liver ribosomes in fed and in fasted rats. J Biol Chem. 1966 Dec 25 241(24):5936-40. p.5938 right column bottom paragraphPubMed ID5954370
|
| Method |
"[Researchers] wished first to determine the kinetics of turnover of liver
cytoplasmic ribosomes under conditions approximating a steady
state in which synthesis is balanced by catabolism. The method
was to label the ribosomal protein and RNA moieties in a series
of animals and to measure the specific activities of these components
at intervals the rate of decrease indicates the rate of
production of unlabeled ribosomes, which in well fed, mature
animals also approximates the rate of degradation." |
| Comments |
"The half-lives of 5 davs for both ribosomal protein and RNA that [researchers] have measured in the livers of well fed rats agree with reported values for the RNA component (17) and for total rat liver RNA (8)." |
| Entered by |
Uri M |
| ID |
110054 |