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Transcriptional accuracy (error rate of RNAP)

Range	<1e-5 mismatch/nucleotide
Organism	bacteria
Reference	Encyclopedia of Biological Chemistry, e-only, S-H Jun, B A Warner, and K S Murakami, The Pennsylvania State University, University Park, PA, USA, RNA Polymerase Reaction in Bacteria, 2013 Elsevier Inc p.170 right column 3rd paragraph
Comments	"Transcriptional accuracy of bacterial RNAP is relatively high with an estimated error rate of less than 10^-5. RNAP secures transcriptional fidelity by using two strategies, substrate selection and proofreading, which remove a mismatched nucleotide from nascent RNA by RNA cleavage activity."
Entered by	Uri M
ID	109867