Sodium entry through NMDA receptor channel for each synaptic vesicle released
| Value | 210000 Na+/vesicle |
|---|---|
| Organism | Unspecified |
| Reference | Attwell D, Laughlin SB. An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab. 2001 Oct21(10):1133-45. p.1136 left column top paragraphPubMed ID11598490 |
| Comments | "Taking an average value of 1, and noting that 10% of the charge influx is carried by Ca2+ rather than Na+ (Burnashev et al., 1995), this implies an entry of 180,000 Na+ and 10,000 Ca2+ per vesicle of glutamate released. Each Ca2+ is extruded by 3 Na+/Ca2+ exchange, leading to the entry of an extra 30,000 Na+, so the total Na+ entry is 210,000 ions requiring hydrolysis of 70,000 ATP molecules for their extrusion." |
| Entered by | Uri M |
| ID | 108625 |