Myocyte turnover in the female heart

Range 10%/year age 20: 14%/year age 60: 40%/year age 100 %/year
Organism Human Homo sapiens
Reference Kajstura J et al., Myocyte turnover in the aging human heart. Circ Res. 2010 Nov 26 107(11):1374-86. doi: 10.1161/CIRCRESAHA.110.231498. p.1384 left column bottom paragraphPubMed ID21088285
Method P.1384 left column bottom paragraph: "The results of the present study indicate that myocyte regeneration in the physiologically aging heart takes place at previously unexpected levels in both women and men. In view of their similarity, the data obtained by the hierarchical model of myocyte renewal and those based on population dynamics were combined."
Comments Abstract: "At all ages, the female heart is equipped with a larger pool of functionally competent hCSCs (human cardiac stem cells) and younger myocytes than the male myocardium." P.1384 left column bottom paragraph: "In the female heart, myocyte replacement occurs at a rate of 10%, 14%, and 40% per year at 20, 60, and 100 years of age, respectively. Corresponding values in the male heart are 7%, 12%, and 32% per year, documenting that myocyte turnover involves a large and progressively increasing number of parenchymal cells with aging." See BNID 107076
Entered by Uri M
ID 107077