Cardiomyocyte renewal rate

Range 1%/year at age 25: 0.45%/year at age 75 %/year
Organism Human Homo sapiens
Reference Bergmann O et al., Evidence for cardiomyocyte renewal in humans. Science. 2009 Apr 3 324(5923):98-102. p.101 right column 2nd paragraph and fig.4bPubMed ID19342590
Method "[Researchers] first carbon-dated left ventricle myocardial cells, including cardiomyocytes and other cell types, to determine the extent of postnatal DNA synthesis in the human heart. DNA was extracted, and 14C concentrations were measured by accelerator mass spectrometry (see tables S1 and S2 for 14C values and associated data)."
Comments "[Investigators] next tested a series of different models allowing turnover rates to change with age. The best fit was found with an inverse-linear declining turnover rate (Fig. 4B), in which younger cardiomyocytes were more likely than older ones to be replaced (see supporting online text). This model predicts that cardiomyocytes are renewed at a rate of ~1% per year at the age of 25 and 0.45% at the age of 75 (Fig. 4B). With this turnover rate, most cardiomyocytes will never be exchanged during a normal life span (Fig. 4C)" See BNID 107077, 107078
Entered by Uri M
ID 107076