Number of essential genes

Range ~300 Genes
Organism Bacteria Escherichia coli
Reference Ghosh K, Dill K. Cellular proteomes have broad distributions of protein stability. Biophys J. 2010 Dec 15 99(12):3996-4002. p.3999 right column paragraph above bottom paragraphPubMed ID21156142
Primary Source Baba et al., Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol Syst Biol. 2006 2: 2006.0008.PubMed ID16738554
Method Researchers compute the thermal stabilities of whole proteomes using an analytical model and an extensive database of stabilities of individual proteins.
Entered by Uri M
ID 107072