Temperature range of denaturation catastrophe

Range 49°C to 55°C °C
Organism Bacteria Escherichia coli
Reference Ghosh K, Dill K. Cellular proteomes have broad distributions of protein stability. Biophys J. 2010 Dec 15 99(12):3996-4002. p.3997 right column bottom paragraphPubMed ID21156142
Method Researchers compute the thermal stabilities of whole proteomes using an analytical model and an extensive database of stabilities of individual proteins.
Comments The model predicts a denaturation catastrophe around 49– 55°C, consistent with the observed cell-death temperature in E. coli (Ratkowsky et al., 1983 PMID 6853443). 55°C is the proteome denaturation midpoint. See BNID 105002
Entered by Uri M
ID 107071