| Range |
49°C to 55°C °C
|
| Organism |
Bacteria Escherichia coli |
| Reference |
Ghosh K, Dill K. Cellular proteomes have broad distributions of protein stability. Biophys J. 2010 Dec 15 99(12):3996-4002. p.3997 right column bottom paragraphPubMed ID21156142
|
| Method |
Researchers compute the thermal stabilities of whole proteomes using an analytical model and an extensive database of stabilities of individual proteins. |
| Comments |
The model predicts a denaturation catastrophe around 49–
55°C, consistent with the observed cell-death temperature
in E. coli (Ratkowsky et al., 1983 PMID 6853443). 55°C is the proteome
denaturation midpoint. See BNID 105002 |
| Entered by |
Uri M |
| ID |
107071 |