Rule of thumb for fastest theoretical replication time

Range ~8 Minutes
Organism Bacteria Escherichia coli
Reference Dill KA, Ghosh K, Schmit JD. Physical limits of cells and proteomes. Proc Natl Acad Sci U S A. 2011 Nov 1 108(44):17876-82 p.17880 right column bottom paragraphPubMed ID22006304
Method If every protein molecule in E. coli were a ribosomal protein, then each ribosome (a 55-protein complex of about 7,400 amino acids) would need only to synthesize its own 55 proteins in series, not 3 million. In this limit, E. coli could replicate in around 8 min [7,400/15aa/sec].
Comments This is a simple “ballpark” estimate, not expected to be good to better than a factor of two or three. In reality, E. coli is able to replicate at a speed that is exceedingly close to this maximum possible physical speed limit.
Entered by Uri M
ID 107063