| Comments |
P.141 left column bottom paragraph: "Antigens in the remaining 23 systems are defined by the protein sequence of red cell membrane proteins (Table 1). [Investigators'] knowledge of the relative abundance of different blood group-active proteins derives in large part from quantitation of antigen sites using labelled monoclonal antibodies (whole antibodies or Fab). Data obtained in this way are consistent with most blood group-active proteins being minor constituents of the red cell membrane ([4], Table 1). A small subset of proteins are major constituents and these comprise the major anion transport protein which expresses antigens of the DI system (band 3, AE1), Glycophorins (A, B which express MNS system antigens and C, D which express GE system antigens) Rh polypeptides (D and CE), Rh-associated glycoprotein (RhAG) and Aquaporin 1 (AQP1) which expresses CO system antigens. Band 3 and Glycophorin A (GPA) are the most abundant red cell surface proteins with each comprising ca. 106 copies/cell. The other proteins in this subset comprise 1–2.5 × 10^5 copies/cell (Table 1)." See BNID 105173 |