| Value |
1.1E-08
Mutations/site/generation
Range: 6.8E-09 to 1.7E-08 Mutations/site/generation
|
| Organism |
Human Homo sapiens |
| Reference |
Roach et al., Analysis of genetic inheritance in a family quartet by whole-genome sequencing. Science. 2010 Apr 30 328(5978):636-9. p.637 right column bottom paragraphPubMed ID20220176
|
| Method |
Whole genome sequencing of parents and their 2 siblings. |
| Comments |
Adjusting for the false-negative rate produced
an unbiased mutation rate estimate of 1.1×10^-8
per position per haploid genome, corresponding
to approximately 70 new mutations in each
diploid human genome. Range is 95% confidence intervals. For 1.8E-08 in a study of 20 Mendelian diseases see Kondrashov 2003 PMID 12497628. See BNID 100414, 105813 |
| Entered by |
Uri M |
| ID |
105919 |