Area of cholesterol on heterogeneous membrane

Value 0.223 nm^2
Organism Generic
Reference Edholm O, Nagle JF. Areas of molecules in membranes consisting of mixtures. Biophys J. 2005 Sep89(3):1827-32. p. 1827 right column and p. 1827 right column 3rd paragraph and p.1828 fig.1PubMed ID15994905
Primary Source [16] Chiu SW, Jakobsson E, Mashl RJ, Scott HL. Cholesterol-induced modifications in lipid bilayers: a simulation study. Biophys J. 2002 Oct83(4):1842-53.PubMed ID12324406
Comments P.1827 right column 3rd paragraph: "The most obvious method assumes that the partitioned areas aDPPC(x) and achol(x) are constants independent of x. Then, the plot of a(x) versus x should be a straight line. In this way, Chiu et al. (primary source) obtained the results aDPPC = 0.507 nm^2 and achol = 0.223 nm^2 for large values of x. However, Fig. 1 suggests that a linear fit is inadequate for small values of x." For large values of x. See BNID 105804 Table- for range in various values of x. See BNID 102781, 105300, 106107
Entered by Uri M
ID 105805