| Value |
4.7E-05
(Substitution/generation)^2
|
| Organism |
Budding yeast Saccharomyces cerevisiae |
| Reference |
Landry CR, Lemos B, Rifkin SA, Dickinson WJ, Hartl DL. Genetic properties influencing the evolvability of gene expression. Science. 2007 Jul 6 317(5834):118-21PubMed ID17525304
|
| Method |
Researchers performed a mutation-accumulation (MA)
experiment (Fig. 1A) in S. cerevisiae in order to
isolate the contribution of the mutational process
to gene expression evolution.With serial transfer
of random colonies, they accumulated spontaneous
mutations by maintaining parallel lines with
effective population sizes of ~10 individuals. The
lines diverged from an isogenic common ancestor
for 4000 generations. They estimated the Vm
of gene expression for genes that showed
significant statistical differences (Bayesian posterior
probability > 0.99) in expression among
any pair of the four MA lines by using logtransformed
relative expression levels. |
| Comments |
The rate of phenotypic evolution due to
mutation alone can be measured by the mutational
variance (Vm), which is defined as the
increase in the variance of a trait introduced by
mutations each generation. It can be calculated
from the variance of traits among MA (mutation accumulation) lines. For
haploid asexual organisms, Vm = 2sb^2/t, where
sb^2 is the between-line variance and t is the
number of generations. See BNID 105091 |
| Entered by |
Uri M |
| ID |
105090 |