| Range |
Table - link
|
| Organism |
Various |
| Reference |
Itzkovitz S, Tlusty T, Alon U. Coding limits on the number of transcription factors. BMC Genomics. 2006 Sep 19 7: 239.PubMed ID16984633
|
| Method |
Researchers used the superfamily database (version
1.69) to obtain the numbers of TFs from each superfamily
in different organisms. Position-Specific Score Matrices (PSSM) for 46 E. coli transcription
factors, were constructed based on the RegulonDB
database [66]. To measure the similarity between binding sequences of a
pair of factors researchers assessed the distances between their
PSSMs. Measurement of similarity of biological function of TFs. Assessment of the number of possible sequences. |
| Comments |
Transcription factor proteins bind specific DNA sequences to control the expression of genes. They contain DNA binding domains which belong to several super-families, each with a specific mechanism of DNA binding. The total number of transcription factors encoded in a genome increases with the number of genes in the genome. Here, researchers examined the number of transcription factors from each super-family in diverse organisms. The present study suggests that there are
upper bounds on the number of transcription factors
from different super-families. It seems that the more constrained
the binding mechanism, the lower the bound.
The present bounds may be understood in terms of an
optimal coding strategy, in which misrecognition errors
are minimized. |
| Entered by |
Uri M |
| ID |
104996 |