| Value |
36
divisions/generation
Range: Table - link divisions/generation
|
| Organism |
Fruit fly Drosophila melanogaster |
| Reference |
Lynch M. et al., A genome-wide view of the spectrum of spontaneous mutations in yeast. Proc Natl Acad Sci U S A. 2008 Jul 8 105(27):9272-7. doi: 10.1073/pnas.0803466105. p.9276 left column 2nd paragraph and note under table 3PubMed ID18583475
|
| Primary Source |
Drost JB, Lee WR. Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among drosophila, mouse, and human. Environ Mol Mutagen. 1995 25 Suppl 26:48-64. DOI: 10.1002/em.2850250609PubMed ID7789362
|
| Method |
Primary source (p. 54 left column 2nd paragraph:)- "figures 2-7 - link [link shows only fig.2-3] are diagrammatic summaries of the cell divisions and other major events in the male and female germlines of Drosophila melanogaster, Mus musculus, and Homo supiens through a complete generation in both sexes. These are based on data from the scientific literature, using both classical and modern molecular techniques, in the fields of embryology, cell lineage analysis, mosaic studies, stem cell renewal strategies, gametogenesis, and developmental genetics [Drost, 1993]." For formula of timing number of male germline cell lines in higher animals see p. 55 eq. 6 |
| Comments |
Note beneath table 3:"D. melanogaster: mutation rate estimates (refs 8, 52–55): assumes 36 germ-line cell divisions per generation (primary source)." Primary source abstract:"Recent estimates of the number of germ cell divisions per generation are: for humans, 401 (30-year generation) in males and 31 in females, for mice, 62 (9-month generation) in males and 25 in females and for Drosophila melanogaster, 35.5 (18-day generation) in males and 36.5 (25-day generation) in females." |
| Entered by |
Uri M |
| ID |
103523 |