Ratio between Km (nonsense codon)/Km (sense codon) of class I release factor

Range 100-1000 Unitless
Organism Bacteria Escherichia coli
Reference Hani S. Zaher and Rachel Green, Fidelity at the Molecular Level: Lessons from Protein Synthesis. Cell Volume 136, Issue 4, 20 February 2009, Pages 746-762PubMed ID19239893
Method pre-steady-state kinetic experiments.
Comments class I release factor specificity derives from a relatively large apparent binding (Km) contribution (2 to 3 orders of magnitude over sense-codon recognition), indicating that all sense codons trigger decreased class I release factor binding.
Entered by Uri M
ID 103489