Overall selectivity of tRNA binding to ribosome under competitive conditions

Value 450 Fold
Organism Bacteria Escherichia coli
Reference Hani S. Zaher and Rachel Green, Fidelity at the Molecular Level: Lessons from Protein Synthesis. Cell Volume 136, Issue 4, 20 February 2009, Pages 746-762PubMed ID19239893
Method pre-steady-state kinetic experiments.
Comments This value nicely matches the product of the initial selection and proofreading parameters (30 × 15) measured in the absence of competition in: K.B. Gromadski and M.V. Rodnina, Kinetic determinants of high-fidelity tRNA discrimination on the ribosome, Mol. Cell 13 (2004), pp. 191–200, pubmed ID 14759365
Entered by Uri M
ID 103481