Diameter of arginine vasopressin synthesizing neuron in the hypothalamic supraoptic nucleus

Value 19.7 µm Range: Table - link µm
Organism Human Homo sapiens
Reference Ishunina TA, Swaab DF. Vasopressin and oxytocin neurons of the human supraoptic and paraventricular nucleus: size changes in relation to age and sex. J Clin Endocrinol Metab. 1999 Dec84(12):4637-44. p.4640 Table IPubMed ID10599731
Method As the shape of the neuron is ellipsoide, it necessitated the measurements of two axis for an appropriate estimation of the neuron volume. The shortest (Dmin) and largest (Dmax) diameters of cell somata crossing under the angle of 90° were measured in immunocytochemically stained arginine vasopressin (AVP) and oxytocin (OT) neurons with a nucleolus by means of an ocular micrometer. Cell somata volumes (Vcs) were subsequently calculated according to the formula of a prolate spheroid p×a×b^2/6, where a is the Dmax, and b is the Dmin. Cell nucleus volumes (Vcn) were calculated using the formula of the sphere volume 4×r^3/3 (32), where r is the radius of the sphere. Dmin and Dmax as well as the corresponding cell volume were calculated for each neuron separately.
Comments Value is mean of short diameter 14.8±1µm and long diameter 24.6±0.8µm in males under the age of 50.
Entered by Uri M
ID 103017