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Rate of production of non-nucleated reticulocytes in adult

Value	2e+6 cells/sec
Organism	Human Homo sapiens
Reference	Chen K, Liu J, Heck S, Chasis JA, An X, Mohandas N. Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis. Proc Natl Acad Sci U S A. 2009 Oct 13 106(41):17413-8.PubMed ID19805084
Comments	During terminal erythroid differentiation, proerythroblasts, the earliest morphologically recognizable nucleated erythroid cells in hematopoietic tissues (normally bone marrow), undergo 3–4 mitoses to generate, in humans, 2 million nonnucleated reticulocytes every second. Extensive remodeling of reticulocytes, first in the bone marrow and then in circulation, results in the generation of mature circulating red cells with their unique discoid shape and membrane material properties.
Entered by	Uri M
ID	102746