pKa of selenocysteine
| Value | 5.2 unitless |
|---|---|
| Organism | Generic |
| Reference | Axley MJ, Böck A, Stadtman TC. Catalytic properties of an Escherichia coli formate dehydrogenase mutant in which sulfur replaces selenium. Proc Natl Acad Sci U S A. 1991 Oct 188(19):8450-4.PubMed ID1924303 |
| Comments | While the selenol of free selenocysteine has a pKa of 5.2, the thiol of free cysteine has a pKa greater than 8. Therefore, at physiological pH values a selenol group is almost fully ionized, while a thiol group is largely protonated. |
| Entered by | Uri M |
| ID | 102619 |