Replication errors per genome

Value 2.5e-3 Unitless
Organism Bacteria Escherichia coli
Reference Drake JW, A constant rate of spontaneous mutation in DNA-based microbes.Proc Natl Acad Sci U S A. 1991 Aug 15 88(16):7160-4 Table 1PubMed ID1831267
Method Value is mean of two strains-hisGDCBHAFE (one measurement), LacI (2 measurements)
Comments A nearly invariant microbial mutation rate appears to have evolved. For a value an order of magnitude lower, 0.0001-0.0002 substitutions/generation, see BNID 105029, 105031
Entered by Uri M
ID 102008