Fraction of DNA that is transcribed according to the Encyclopedia of DNA Elements (ENCODE) project

Value 83.7 %
Organism Human Homo sapiens
Reference Hangauer MJ, Vaughn IW, McManus MT. Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet. 2013 Jun9(6):e1003569. doi: 10.1371/journal.pgen.1003569 p.1 right columnn top paragraph and p.2 right column top paragraphPubMed ID23818866
Primary Source [14] Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, et al. (2012) Landscape of transcription in human cells. Nature 489: 101–108. doi: 10.1038/nature11233PubMed ID22955620
Method Primary source p.101 left column: "The Encyclopedia of DNA Elements (ENCODE) project has sought to catalogue the repertoire of RNAs produced by human cells as part of the intended goal of identifying and characterizing the functional elements present in the human genome sequence [ref 2]."
Comments P.1 left column bottom paragraph: "More recently, a few studies have focused on evaluating the extent of intergenic transcription using sequencing-based approaches, but with the exception of the recently published ENCODE project results [ref 13], [primary source], these studies have thus far been limited to very narrow preselected regions of the genome and a small number of tissues [refs 6, 7]. Overcoming these prior shortcomings, the ENCODE project used RNA-seq analysis in combination with other technologies to profile 15 human cell lines, providing evidence for transcription across 83.7% of the human genome and firmly establishing the reality of pervasive transcription [primary source]." P.2 right column top paragraph: "This result closely agrees with the recently published findings from the ENCODE project in which evidence for transcription of 83.7% of the genome was uncovered [primary source]."
Entered by Uri M
ID 115144