Fraction of male recombination jungles (genomic regions with higher recombination counts) that are located in the 5% most telomeric parts of chromosomes

Value 70 % of male recombination jungles
Organism Human Homo sapiens
Reference Chowdhury R, Bois PR, Feingold E, Sherman SL, Cheung VG. Genetic analysis of variation in human meiotic recombination. PLoS Genet. 2009 Sep5(9):e1000648. doi: 10.1371/journal.pgen.1000648 p.7 left column bottom paragraphPubMed ID19763160
Method Abstract: "In this study, [investigators] used high-density SNP genotypes of over 2,300 individuals and their offspring in two datasets to characterize recombination landscape and to map the genetic variants that contribute to variation in recombination phenotypes."
Comments P.2 right column bottom paragraph: "Recombination events are not distributed evenly across the human genome [ref 15]. [Investigators] refer to genomic regions with higher recombination counts ... as "recombination jungles" [ref 2],[ref 15] (rather than hotspots, which are only hundreds of base pairs in size)." P.7 left column bottom paragraph: "[Investigators] used a sample of 1,295 two-generation families with multiple offspring to study the recombination landscape and the genetic basis of meiotic recombination. [Their] analysis showed that the locations of the recombination events differ across the genome, most of the crossovers occur at the ends of chromosomes. In particular, 70% of male recombination jungles are located in the 5% most telomeric parts of chromosomes."
Entered by Uri M
ID 115346