| Value |
70
% of male recombination jungles
|
| Organism |
Human Homo sapiens |
| Reference |
Chowdhury R, Bois PR, Feingold E, Sherman SL, Cheung VG. Genetic analysis of variation in human meiotic recombination. PLoS Genet. 2009 Sep5(9):e1000648. doi: 10.1371/journal.pgen.1000648 p.7 left column bottom paragraphPubMed ID19763160
|
| Method |
Abstract: "In this study, [investigators] used high-density SNP genotypes of over 2,300 individuals and their offspring in two datasets to characterize recombination landscape and to map the genetic variants that contribute to variation in recombination phenotypes." |
| Comments |
P.2 right column bottom paragraph: "Recombination events are not distributed evenly across the human genome [ref 15]. [Investigators] refer to genomic regions with higher recombination counts ... as "recombination jungles" [ref 2],[ref 15] (rather than hotspots, which are only hundreds of base pairs in size)." P.7 left column bottom paragraph: "[Investigators] used a sample of 1,295 two-generation families with multiple offspring to study the recombination landscape and the genetic basis of meiotic recombination. [Their] analysis showed that the locations of the recombination events differ across the genome, most of the crossovers occur at the ends of chromosomes. In particular, 70% of male recombination jungles are located in the 5% most telomeric parts of chromosomes." |
| Entered by |
Uri M |
| ID |
115346 |