Lifespan of average β-cell

Range 20 to 50 Days
Organism Rat Rattus norvegicus
Reference Finegood DT, Scaglia L, Bonner-Weir S. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes. 1995 Mar44(3):249-56. p.254 fig.7 dotted linePubMed ID7883109
Method Mathematical model. "The generic mass balance equation states that the rate of entry of new cells minus the rate of loss of cells will equal the rate of change of the number of cells in the mass. In the case of the ß-cell mass, there are two processes that could contribute new cells: replication of preexisting ß-cells and formation of new islets by differentiation of ductal precursors (neogenesis)." Value estimated visually from fig.7
Comments Caption to fig.7: "Estimation of the life span of the ß-cell using the mathematical model to generate the total rate of appearance of new cells and the disappearance of dying cells on any given day. These estimates are based on a series of assumptions about cell age, i.e., that the oldest cells die first and that after replication, one daughter cell retains the age of the parent cell and one is considered new. The estimated life span of the ß-cell is highly dependent on the replication rate in the adult. The graph was generated using Eq.1, but because the data on replication from 50 to 100 days were between 1 and 4%, the life span of the rat ß-cell is likely to be >1 month but <3 Months." See BNID 107081
Entered by Uri M
ID 109228