Mutation rate per base pair per replication

Value 2.2E-10 mutation/bp/replication Range: Table - link mutation/bp/replication
Organism Budding yeast Saccharomyces cerevisiae
Reference Drake JW, Charlesworth B, Charlesworth D, Crow JF. Rates of spontaneous mutation. Genetics. 1998 Apr148(4):1667-86. p.1670 table 4PubMed ID9560386
Method The typical procedure is to estimate C (the reciprocal of the efficiency of mutation detection), then to calculate the mutant frequency f, then the mutation rate µt of the measured target sequence, then the mutation rate µbp of the average base pair (dividing µt by the size of the target sequence), then the mutation rate µg of the entire genome (multiplying µbp by the number of base pairs per genome).
Comments "Mutation rates in DNA-based microbes: Rates of spontaneous mutation in this class of organisms were last surveyed in Drake (1991) and are summarized in Table 4 using a few updated values for genome sizes. Unlike the experimental and theoretical limits to the accuracy of the RNA-virus values, the DNA-microbe values were determined in well-studied systems using robust calculations, and the individual values are likely to be accurate to within two-fold. Table 4 shows that µb and G vary inversely and smoothly over nearly four orders of magnitude while µg remains constant. Given the paucity of general, constant values in evolutionary processes, this particular constant is strikingly robust." For description of parameters see link
Entered by Ron Milo - Admin
ID 100457