Half life of histone mRNA

Value 7 min Range: ±2 min
Organism Budding yeast Saccharomyces cerevisiae
Reference Wang Y, Liu CL, Storey JD, Tibshirani RJ, Herschlag D, Brown PO. Precision and functional specificity in mRNA decay. Proc Natl Acad Sci U S A. 2002 Apr 30 99(9):5860-5 p.5862 right column 3rd paragraphPubMed ID11972065
Method By using DNA microarrays, researchers precisely measured the decay of each yeast mRNA, after thermal inactivation of a temperature-sensitive RNA polymerase II.
Comments The half-lives of the 4,687 mRNAs analyzed varied widely, ranging from ~3 min to more than 90 min, with a mean of 23 min and median of 20 min. The nucleosome core is composed of four histone subunits, in equimolar proportions, assembled into an octamer (ref 29). The 4 distinguishable histone mRNAs have closely matched, rapid decay rates, with t1/2=7±2min
Entered by Uri M
ID 104742