Loss of brain weight from ages 50 - 90

Range 2-3 % per decade
Organism Human Homo sapiens
Reference Stark AK, Pakkenberg B. Histological changes of the dopaminergic nigrostriatal system in aging. Cell Tissue Res. 2004 Oct318(1):81-92. DOI: 10.1007/s00441-004-0972-9 p.81 right column 2nd paragraphPubMed ID15365813
Comments P.81 right column 2nd paragraph: "In humans, brain weight, brain volume, and the total number of brain cells are greatest in the early teens, with no or only a small loss over the first five or six decades of adult life (Esiri et al. 1997 Pakkenberg and Gundersen 1997). From 50 to 90 years of age, the loss of brain weight is approximately 2%–3% per decade. An increase in ventricular volume and the total amount of cerebrospinal fluid indicates a reduction in the volume of the brain during aging, but the precise location from where this loss occurs is difficult to pinpoint. Postmortem studies have found a significant reduction in the volume of the neocortex, archicortex, and white brain matter, whereas the volume of the central gray nuclei is not significantly reduced as a function of age." See BNID 112057
Entered by Uri M
ID 113114