Number of sites on red blood cell surface that phloretin binds to

Range ~2.5E+6 sites/cell
Organism Human Homo sapiens
Reference Forster RE, Gros G, Lin L, Ono Y, Wunder M. The effect of 4,4'-diisothiocyanato-stilbene-2,2'-disulfonate on CO2 permeability of the red blood cell membrane. Proc Natl Acad Sci U S A. 1998 Dec 22 95(26):15815-20. p.15819 right column bottom paragraphPubMed ID9861053
Primary Source Jennings ML, Solomon AK. Interaction between phloretin and the red blood cell membrane. J Gen Physiol. 1976 Apr67(4):381-97.PubMed ID5575
Comments "The self-exchange of HCO3- in red cells through Band III (capnophorin) is extremely rapid, and the cells have an effective permeability under physiological conditions of 4X10^-4 cm/sec (ref 1), with about 2.5 million proteins per cell (primary source), but this is about 1/10,000 of [researchers'] minimal estimate of CO2 permeability."
Entered by Uri M
ID 110622