Fraction of red blood cell membrane that is protein

Range ≥50 %
Organism Human Homo sapiens
Reference Forster RE, Gros G, Lin L, Ono Y, Wunder M. The effect of 4,4'-diisothiocyanato-stilbene-2,2'-disulfonate on CO2 permeability of the red blood cell membrane. Proc Natl Acad Sci U S A. 1998 Dec 22 95(26):15815-20. p.15819 right column bottom paragraphPubMed ID9861053
Primary Source Guidotti, G. (1978) in Membrane Physiology, eds. Andreoli, T. E., Hoffman, J. F. & Fanestil, D. D. (Plenum, New York), pp. 49–60.
Comments P.15819 right column bottom paragraph: "For CO2 to permeate by means of a membrane protein is not unreasonable and has been suggested before (refs 15, 24). The human red cell membrane is at least 50% protein (primary source). CO2 would have to pass through a channel or pore rather than by a saturating process, which would be too slow." See Skotland et al., 2017 PMID 28342835 p.38 left column 5th paragraph: "As the plasma membrane of most cells has been estimated to contain approximately 50% of proteins [ref 88 Dupuy & Engelman 2008 PMID 18287056 DOI: 10.1073/pnas.0712379105],..."
Entered by Uri M
ID 110621