Mutation rates at URA3 and CAN1

Range 3.8e-10 at URA3: 6.44e-10 at CAN1 1/bp/generation
Organism Budding yeast Saccharomyces cerevisiae
Reference Lang GI, Murray AW. Estimating the per-base-pair mutation rate in the yeast Saccharomyces cerevisiae. Genetics. 2008 Jan178(1):67-82. doi: 10.1534/genetics.107.071506. p.68 right column top paragraphPubMed ID18202359
Method "Typically, fluctuation assays are performed in test tubes: however, to increase the throughput, [researchers] perform the assays in 96-well plates."
Comments "Combining...estimates of phenotypic mutation rates and locus-specific effective target sizes, [researchers] conclude that the per-base-pair mutation rates at URA3 and CAN1 are 3.80?10^-10 and 6.44?10^-10/bp/generation, respectively, suggesting that the mutation rate varies across the yeast genome."
Entered by Uri M
ID 110018