Rate constant of Fenton's reaction Fe(2+)+H2O2→ Fe(3+)+OH·+OH−

Value 76 M^-1×sec^-1
Organism Generic
Reference Woodmansee AN, Imlay JA. Reduced flavins promote oxidative DNA damage in non-respiring Escherichia coli by delivering electrons to intracellular free iron. J Biol Chem. 2002 Sep 13 277(37):34055-66 p.34056 left column top paragraphPubMed ID12080063
Primary Source Walling, C. Fenton's reagent revisited (1975) Acc. Chem. Res. 8, 125–131
Comments P.34056 left column top paragraph: "In fact, the efficiency with which exogenous H2O2 damages DNA provides evidence that iron re-reduction must be rapid. When Escherichia coli is treated with 2.5 mM H2O2, DNA damage is generated at a high rate for up to 20 min (ref 13). At this concentration of H2O2 the Fenton reaction (76 M^-1×s^-1 (primary source)) should oxidize pre-existing reduced iron within seconds-the observation that damage occurs steadily indicates that a reductant recycles the iron very efficiently."
Entered by Uri M
ID 105678