Oxygen/glucose consumption rate by T cell

Range 2-3 nmole oxygen/nmole glucose
Organism Mouse Mus musculus
Reference Rathmell JC, Farkash EA, Gao W, Thompson CB. IL-7 enhances the survival and maintains the size of naive T cells. J Immunol. 2001 Dec 15 167(12):6869-76. p.6875 left column 2nd paragraphPubMed ID11739504
Comments In contrast to T cell activation, T cell neglect results in a decrease in glycolysis while oxidative phosphorylation is maintained at or near the level of freshly isolated cells. This results in a relative increase in dependence on oxidative phosphorylation and represents a switch from ~2–3 nmole oxygen/nmole glucose consumed in freshly isolated T cells compared with ~4–6 nmole oxygen/nmole glucose consumed in neglected T cells.
Entered by Uri M
ID 102644