Concentration of Ca2+ in lysosome

Range 0.5-0.6 mM
Organism Eukaryotes
Reference Zhong XZ et al., Methods for monitoring Ca2+ and ion channels in the lysosome. Cell Calcium. 2017 Jun64: 20-28. doi: 10.1016/j.ceca.2016.12.001 p.21 right column 2nd paragraphPubMed ID27986285
Primary Source [6] A.J. Morgan, F.M. Platt, E. Lloyd-Evans, A. Galione Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease Biochem. J., 439 (2011), pp. 349-374 doi: 10.1042/BJ20110949 [39] K.A. Christensen, J.T. Myers, J.A. Swanson pH-dependent regulation of lysosomal calcium in macrophages J. Cell Sci., 115 (2002), pp. 599-607PubMed ID21992097, 11861766
Comments P.21 right column 2nd paragraph: "Mounting evidence suggests that the lysosome itself is an important Ca2+ reservoir (0.5–0.6 mM Ca2+) [primary sources] that releases Ca2+ to trigger lysosomal membrane trafficking [primary source 6, refs 1,4,10,32,40]."
Entered by Uri M
ID 114028