Typical speed of ribosomal RNA transcription

Range ~70 nts/sec
Organism Bacteria Escherichia coli
Reference Chen H, Shiroguchi K, Ge H, Xie XS. Genome-wide study of mRNA degradation and transcript elongation in Escherichia coli. Mol Syst Biol. 2015 Jan 12 11(1):781. doi: 10.15252/msb.20145794. p.4 right column 2nd paragraphPubMed ID25583150
Primary Source Roberts JW, Shankar S, Filter JJ (2008) RNA polymerase elongation factors. Annu Rev Microbiol 62: 211–233 doi: 10.1146/annurev.micro.61.080706.093422.PubMed ID18729732
Method Abstract:"Here, [investigators] report a genome-wide RNA degradation study in Escherichia coli using RNA-seq, and present evidence that the stereotypical exponential RNA decay curve obtained using initiation inhibitor, rifampicin, consists of two phases: residual RNA synthesis, a delay in the interruption of steady state that is dependent on distance relative to the mRNA's 5' end, and the exponential decay."
Comments P.4 right column 2nd paragraph:"A few of the mRNA transcription rates are in the range of speeds typically associated with ribosomal RNA transcription (~70 nt/s) and may be the consequence of regulation by transcriptional elongation factors (primary source)."
Entered by Uri M
ID 112327