Fraction of poly(A) RNA that never leaves the nucleus

Range ≤30 %
Organism Mammals
Reference Politz JC et al., Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm. Mol Biol Cell. 2006 Mar17(3):1239-49. p.1239 right column bottom paragraphPubMed ID16371503
Primary Source Perry, R. P., Kelley, D. E., and LaTorre, J. (1974). Synthesis and turnover of nuclear and cytoplasmic polyadenylic acid in mouse L cells. J. Mol. Biol. 82, 315–331. & Herman, R. C., Williams, J. G., and Penman, S. (1976). Message and nonmessage sequences adjacent to poly(A) in steady state heterogeneous nuclear RNA of HeLa cells. Cell 7, 429–437.PubMed ID4856346, 59633
Comments p.1239 right column bottom paragraph:"One idea has been that perhaps there is a metabolically stable, nucleus-restricted poly(A) RNA population that helps to organize and structurally define certain nuclear bodies such as speckles (Fakan et al., 1984 Huang et al., 1994 Lamond and Spector, 2003). This idea stems from observations that as much as 30% of the poly(A) RNA never leaves the nucleus in growing mammalian cells (primary sources). At least some of this poly(A) RNA consists of noncoding sequences that seem to have a variety of nuclear functions (Morey and Avner, 2004)."
Entered by Uri M
ID 111846