Fraction of Insertions-by-duplication out of all insertions in natural genomes

Range ~2/3 (approximately two-thirds) unitless
Organism Eukaryotes
Reference Kipnis Y, Dellus-Gur E, Tawfik DS. TRINS: a method for gene modification by randomized tandem repeat insertions. Protein Eng Des Sel. 2012 Sep25(9):437-44. doi: 10.1093/protein/gzs023. p.437 right column 2nd paragraphPubMed ID22670060
Primary Source Denver DR, Morris K, Lynch M, Thomas WK. High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome. Nature. 2004 Aug 5 430(7000):679-82. & Lynch M et al., A genome-wide view of the spectrum of spontaneous mutations in yeast. Proc Natl Acad Sci U S A. 2008 Jul 8 105(27):9272-7. doi: 10.1073/pnas.0803466105. & Gao X, Lynch M. Ubiquitous internal gene duplication and intron creation in eukaryotes. Proc Natl Acad Sci U S A. 2009 Dec 8 106(49):20818-23. doi: 10.1073/pnas.0911093106.PubMed ID15295601, 18583475, 19926850
Comments "Indels are seen along the evolutionary history of every protein family, and are often the driving force for the acquisition of new functions and structures (Pikkemaat and Janssen, 2002 Park et al., 2006). Insertions-by-duplication seem to play a special role, as approximately two-thirds of insertions observed in natural genomes are of this type (primary sources)."
Entered by Uri M
ID 111536