Decrease in MHC class I alleles in tapasin deficient mice

Value 100 Fold
Organism Mouse Mus musculus
Reference Peaper DR, Cresswell P. Regulation of MHC class I assembly and peptide binding. Annu Rev Cell Dev Biol. 200824:pp. 353PubMed ID18729726
Primary Source Garbi N, Tan P, Diehl AD, Chambers BJ, Ljunggren HG, Momburg F, Hämmerling GJ. Impaired immune responses and altered peptide repertoire in tapasin-deficient mice. Nat Immunol. 2000 Sep1(3):234-8 fig. 1cPubMed ID10973281
Method generation, by homologous recombination, mice with deficient tapasin expression
Comments The surface expression of the mouse class I alleles H2-Kb and H2-Db was decreased by approximately 100-fold compared with WT cells but remained 10-fold higher than on TAP-deficient cells.
Entered by Uri M
ID 102662