Rate of receptor internalization in PC12 cells

Value 0.7 min^-1 Range: Table - link min^-1
Organism Rat Rattus norvegicus
Reference Brightman FA and Fell DA, FEBS Lett. Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells. 2000 Oct 6 482(3):169-74 p. 171 table 1PubMed ID11024454
Primary Source Gex-Fabry M, DeLisi C. Receptor-mediated endocytosis: a model and its implications for experimental analysis. Am J Physiol. 1984 Nov247(5 Pt 2):R768-79.PubMed ID6149699
Comments This is made up of reactions 2, 3, 5, 6, 8 in the scheme fig. 1 p. 170. The first step is the binding of EGF (L in the reaction scheme) to the monomeric cell-surface EGFR (Rs), to form a receptor-ligand complex (RL).
Entered by Cellina Cohen-Saidon
ID 100896