Distance between the TATA box and TSS [Transcription Start Site] for TATA box-containing genes

Range 40 - 120 Base pairs
Organism Budding yeast Saccharomyces cerevisiae
Reference Liu X, Bushnell DA, Kornberg RD. RNA polymerase II transcription: structure and mechanism. Biochim Biophys Acta. 2013 Jan1829(1):2-8. doi: 10.1016/j.bbagrm.2012.09.003. p.4 left column bottom paragraphPubMed ID23000482
Primary Source K. Struhl, Molecular mechanisms of transcriptional regulation in yeast, Annu. Rev. Biochem. 58 (1989) 1051–1077.PubMed ID2673007
Comments p.4 left column bottom paragraph:"The distance between the TATA box and TSS is almost always about 30 bp for TATA box-containing genes [BNID 111571]. Consistent with this, the structural model of the minimal open promoter complex constructed from the pol II–TFIIB crystal structure defines a template strand path of approximately 30 residues from the TATA box to the catalytic site [ref 9] and [ref 10]. The notable exception is Saccharomyces cerevisiae, in which the distance from the TATA box to the TSS is 40–120 bp [primary source]."
Entered by Uri M
ID 111572