Average time it takes for a tumor to reach detection size

Range colorectal cancer 25y: leukemias 7y: uterine cancer 10y years
Organism Human Homo sapiens
Reference Tomasetti C, Vogelstein B, Parmigiani G. Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proc Natl Acad Sci U S A. 2013 Feb 5 110(6):1999-2004. doi: 10.1073/pnas.1221068110. p.2000 right column 3rd paragraphPubMed ID23345422
Primary Source (2) Jones S, et al. (2008) Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA 105(11):4283–4288. (14) Bizzozero OJ, Jr., Johnson KG, Jr., Ciocco A (1966) Radiation-related leukemia in Hiroshima and Nagasaki, 1946-1964. I. Distribution, incidence and appearance time. N Engl J Med 274(20):1095–1101. (15) Little MP (2009) Cancer and non-cancer effects in Japanese atomic bomb survivors. J Radiol Prot 29(2A):A43–A59.PubMed ID18337506, 5932020, 19454804
Comments "What fraction of somatic mutations in a tumor actually arises in the precursor cells before tumor initiation? The number (and fraction) of mutations that occurred before tumor initiation can be estimated by subtracting the number of mutations that occurred during tumor progression (the tail of the fish) from the total number. To estimate this value, [researchers] need to know the average time it takes for a tumor to reach detection size. It has been estimated that colorectal cancer requires an average of 25 y (primary source 2), whereas leukemias take 7 y (primary source 14). For uterine cancer a value of 10 y is assumed (primary source 15)."
Entered by Uri M
ID 111247