RNA polymerase I transcription elongation rate

Range 40 - 60 nts/sec
Organism Budding yeast Saccharomyces cerevisiae
Reference Woolford JL Jr, Baserga SJ. Ribosome biogenesis in the yeast Saccharomyces cerevisiae. Genetics. 2013 Nov195(3):643-81. doi: 10.1534/genetics.113.153197. p.645 right column 3rd paragraphPubMed ID24190922
Primary Source French, S. L., Y. N. Osheim, F. Cioci, M. Nomura, and A. L. Beyer, 2003 In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes. Mol. Cell. Biol. 23: 1558–1568. & Kos, M., and D. Tollervey, 2010 Yeast pre-rRNA processing and modification occur cotranscriptionally. Mol. Cell 37: 809–820.PubMed ID12588976, 20347423
Comments "In a single typical yeast cell generation, an astonishing 200,000 ribosomes are produced. To achieve this, RNA polymerase I maintains an elongation rate of 40– 60 nt/sec (primary sources). The ribosome biogenesis machinery consisting of pre-rRNA processing and preribosome assembly factors must keep up this demanding rate of pre-rRNA synthesis." See BNID 109913
Entered by Uri M
ID 110023