Reduction potential of flavin in mitochondrial complex I at pH7.5

Range -0.38 V
Organism Cow Bos Taurus
Reference Hirst J. Mitochondrial complex I. Annu Rev Biochem. 2013 Jun 2 82 :551-75. doi: 10.1146/annurev-biochem-070511-103700. p.557 left column bottom paragraphPubMed ID23527692
Primary Source Sled VD, Rudnitzky NI, Hatefi Y, Ohnishi T. Thermodynamic analysis of flavin in mitochondrial NADH:ubiquinone oxidoreductase (complex I). Biochemistry. 1994 Aug 23 33(33):10069-75.PubMed ID8060976
Comments "The flavin in B. taurus complex I has an unusually low reduction potential, -0.38 V at pH7.5 (primary source), because the oxidized flavin is bound more strongly than the reduced flavin."
Entered by Uri M
ID 109180