Donnan potential across the outer mitochondrial membrane of Human endothelial cell ECV304

Value 43 mV
Organism Human Homo sapiens
Reference Porcelli AM, Ghelli A, Zanna C, Pinton P, Rizzuto R, Rugolo M. pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant. Biochem Biophys Res Commun. 2005 Jan 28 326(4):799-804. p.803 left column top paragraphPubMed ID15607740
Method It is possible for the first time to provide an estimation of the Donnan potential, from the [H+] values in the two compartments (cytosol and intermembrane space) by means of the Nernst equation.
Comments Interestingly, a value of 43 mV was obtained, which is very similar to the voltage required in electrophysiological experiments to switch the conductance of Voltage-dependent anion channel (VDAC) incorporated in a planar membrane from a high to a low conductance (15–40 mV).
Entered by Uri M
ID 107274