Fraction of replicons that are replicated at any given moment

Value 15 %
Organism Eukaryotes
Reference Benjamin Lewin, Genes VIII 2004, p.359 4th paragraph
Method As eukaryotic replicons are 40 to 100 kb long and the rate of replication is ~2,000bp/min it is evident that a mammalian genome could be replicated in ~1hour if all replicons functioned simultaneously. But S phase actually lasts for >6hours in a typical somatic cell, which implies that no more than 15% of the replicons are likely to be active at any given moment.
Comments There are some exceptional cases, such as the early embryonic divisions of the Drosophila embryos, where the duration of S phase is compressed by the simultaneous functioning of a large number of replicons.
Entered by Uri M
ID 106929