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Average size of replicon

Range	100 - 120 kb
Organism	Eukaryotes
Reference	Méchali M. Eukaryotic DNA replication origins: many choices for appropriate answers. Nat Rev Mol Cell Biol. 2010 Oct11(10):728-38. doi: 10.1038/nrm2976. p.734 right column 2nd paragraphPubMed ID20861881
Primary Source	[45] Lebofsky, R., Heilig, R., Sonnleitner, M., Weissenbach, J. & Bensimon, A. DNA replication origin interference increases the spacing between initiation events in human cells. Mol. Biol. Cell 17, 5337–5345 (2006). [127] Brewer, B. J. & Fangman, W. L. Initiation at closely spaced replication origins in a yeast chromosome. Science 262, 1728–1731 (1993).PubMed ID17005913, 8259517
Comments	p.734 right column 2nd paragraph:"Is the mechanism for selecting clusters of replication origins independent from the mechanism for selecting individual origins? Firing at a given DNA replication origin may inhibit firing at nearby origins by an origin interference mechanism (primary sources) that leads to the 100–120 kb average size of a replicon. A specific origin among several flexible origins would be chosen by this mechanism and a local checkpoint response might inhibit this mechanism (Fig. 4)." See BNID 109876
Entered by	Uri M
ID	111772