Fraction of estimated 17,000 HSCs [Hematopoietic Stem Cells] that contributed to hematopoiesis

Range ~30 %
Organism Unspecified
Reference Krueger A, Ziętara N, Łyszkiewicz M. T Cell Development by the Numbers. Trends Immunol. 2017 Feb38(2):128-139. doi: 10.1016/ p.130 top paragraphPubMed ID27842955
Comments P.130 top paragraph: "Reporter-positive cells could subsequently be traced over time throughout the hematopoietic tree. Applying a mathematical model to this system allowed the authors to determine the number of active HSCs and the flux of progenitor cells through the hematopoietic tree, including the residence time and differentiation rates of progenitor cells within stem and progenitor cell populations. Surprisingly, approximately 30% of an estimated 17 000 HSCs contributed to hematopoiesis, a much higher frequency than predicted by transplantation experiments."
Entered by Uri M
ID 113821