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||"The polymerase collision model does not satisfactorily explain the linkage between gene strand bias and essentiality. If the major problem associated with collision between polymerases is replication slow-down, then one would expect higher biases among the genes leading to higher collision rates, i.e. among highly expressed genes. Yet among the >3000 genes expressed during exponential growth in E. coli
(primary source), the essential genes, many of which are expressed at low levels, are highly biased, whereas the highly expressed genes that are not essential are equally distributed between the replicating strands."