Threshold value of change in free energy for ATP hydrolysis needed to maintain normal sodium homeostasis in heart muscle

Value -50 kJ/mole
Organism Rat Rattus norvegicus
Reference Ingwall JS, Balschi JA. Energetics of the Na(+) pump in the heart. J Cardiovasc Electrophysiol. 2006 May17 Suppl 1:S127-S133PubMed ID16686667
Method Researchers used 23Na NMR spectroscopy to track the movement of Na+ across the sarcolemma in real time in the ischemic (zero flow) rat heart.
Comments In the normal beating myocardium, [Na+]i increases as the DeltaG~ATP falls below the threshold value (~-50 kJ/mole) needed to maintain normal Na homeostasis.
Entered by Uri M
ID 103967