Number of connexin channels in gap junctions interconnecting mature interneurons of the neocortex

Range ~150 - 380 connexin channels
Organism Rat Rattus norvegicus
Reference Connors BW, Long MA. Electrical synapses in the mammalian brain. Annu Rev Neurosci. 2004 27: 393-418 DOI: 10.1146/annurev.neuro.26.041002.131128 p.405 2nd paragraphPubMed ID15217338
Primary Source Fukuda T, Kosaka T. Ultrastructural study of gap junctions between dendrites of parvalbumin-containing GABAergic neurons in various neocortical areas of the adult rat. Neuroscience. 2003 120(1):5-20 DOI: 10.1016/s0306-4522(03)00328-2PubMed ID12849736
Method Primary source abstract: "In this study [investigators] examined detailed ultrastructural features of gap junctions between PV [Parvalbumin (PV)-containing GABAergic neurons] neurons in the mature neocortex. Light microscopic observations and confocal laser scanning microscopy revealed frequent dendrodendritic contacts between PV neurons. Electron microscopic analysis provided direct morphological evidence for the existence of gap junctions between 22 pairs of PV-immunoreactive dendrites in the visual, auditory, and somatosensory cortices."
Comments P.405 2nd paragraph: "For example, on the basis of their size, the gap junctions interconnecting mature interneurons of the neocortex have ∼150–380 connexin channels (primary source)."
Entered by Uri M
ID 117165