Number of AMPA receptors per bouton

Range ~20 - 100 AMPA receptors/bouton
Organism Rat Rattus norvegicus
Reference Harris JJ, Jolivet R, Attwell D. Synaptic energy use and supply. Neuron. 2012 Sep 6 75(5):762-77. doi: 10.1016/j.neuron.2012.08.019. p.767 left column bottom paragraphPubMed ID22958818
Comments p.767 left column bottom paragraph:"At different synapses, electrophysiology suggests that 10–70 AMPA receptors are opened by a single vesicle (BNID 111653), while immunogold labels 8–40 postsynaptic AMPA receptors (Nusser et al., 1998). These numbers are underestimates, because the open probability of the receptors at the peak of the synaptic current is less than 1 (even in saturating glutamate) and because some receptors will not be labeled by immunocytochemistry. The probable true density is thus ~20–100 receptors per bouton." AMPA receptor=a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
Entered by Uri M
ID 111654