Number of signal-regulated STAT3 (gene) targets in NIH 3T3 cells

Range ~300 target genes
Organism Mouse Mus musculus
Reference Carroll SB. Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Cell. 2008 Jul 11 134(1):25-36. doi: 10.1016/j.cell.2008.06.030 p.30 right column top paragraphPubMed ID18614008
Primary Source Snyder M, Huang XY, Zhang JJ. Identification of novel direct Stat3 target genes for control of growth and differentiation. J Biol Chem. 2008 Feb 15 283(7):3791-8 DOI: 10.1074/jbc.M706976200PubMed ID18065416
Method Primary source abstract: "Here [investigators] report the identification of novel direct Stat3 target genes using a genome-wide screening procedure based on the chromatin immunoprecipitation method...In addition, using a physiological cell system, [they] demonstrate that Stat3 is required for the transcriptional regulation of two of the newly identified direct Stat3 target genes important for muscle differentiation."
Comments P.30 right column top paragraph: "For example, Stark et al. (BNID 117005) estimated that there are, on average, 124 target genes for each of the 67 Drosophila transcription factors they analyzed. This figure is exceeded by the number of validated hormone-responsive androgen receptor target genes in just one human cell type (172: BNID 117006) and the number of signal-regulated STAT3 targets in another cell type (∼300: primary source)."
Entered by Uri M
ID 117007